Oral 5-Day Lefamulin for Outpatient Management of Community-Acquired Bacterial Pneumonia: Post-hoc Analysis of the Lefamulin Evaluation Against Pneumonia (LEAP) 2 Trial

نویسندگان

چکیده

BackgroundSafe and effective oral antibiotics are needed for outpatient management of moderate to severe community-acquired bacterial pneumonia (CABP).ObjectiveWe describe a post-hoc analysis adults with CABP managed as outpatients from the Lefamulin Evaluation Against Pneumonia (LEAP) 2 double-blind, noninferiority, phase 3 clinical trial.MethodsLEAP compared efficacy safety lefamulin 600 mg every 12 h (5 days) vs. moxifloxacin 400 24 (7 in (inpatients outpatients) Outcomes Research Team (PORT) risk classes II‒IV.ResultsOverall, 41% (151 368) patients receiving 43% (159 started treatment outpatients—44% 40%, respectively, were PORT class III/IV, 21% both groups had CURB-65 scores 2‒3. Early response (at 96 ± h) investigator assessment success rates at test cure (5‒10 days after last study drug dose) high similar among all (lefamulin, 91% moxifloxacin, 89‒90%), III/IV (89‒91% 88‒91%), score 2‒3 (87‒90% 82‒88%) outpatients. Few 2.6%; 2.5%) discontinued because treatment-emergent adverse events (TEAEs). No group was hospitalized TEAE, 5 (3%), including two deaths, group.ConclusionsThese data suggest that can be given lieu fluoroquinolones or

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

In Vitro Activity of Lefamulin against S. aureus Collected Worldwide from Hospitalized Patients with Bacterial Pneumonia

1217. In Vitro Activity of Ceftolozane-Tazobactam vs. Antimicrobial NonSusceptible Pseudomonas aeruginosa Clinical Isolates Obtained from Across Canada as Part of the CANWARD Study, 2008–2016 Andrew Walkty, MD; Heather J. Adam, PhD; Melanie Baxter, MSc; Philippe Lagace-Wiens, MD; James Karlowsky, PhD; Daryl Hoban, PhD and George Zhanel, PhD; Diagnostic Services Manitoba, Winnipeg, MB, Canada, M...

متن کامل

Management of community acquired pneumonia.

P is a common illness which causes significant morbidity and mortality all over the world, despite the availability of better and more potent antibiotics and improvement in supportive care. The problem increases with discrepancy in management despite the availability of guidelines for management. Pneumonia is often misdiagnosed and is commonly treated inadequately or over treated with misuse of...

متن کامل

evaluation and management of community and hospital-acquired pneumonia for the primary care providers

conclusions cap/hap remains one of the leading causes of morbidity and mortality in the world. bacterial resistance is increasing and adds to the difficulty in treating these patients. newer drugs are available but should be used judiciously and in the right setting. context the incidence and prevalence of both community and hospital acquired pneumonia has remained relatively constant over the ...

متن کامل

Clinical evaluation of the role of ceftaroline in the management of community acquired bacterial pneumonia

Ceftaroline fosamil (ceftaroline) was recently approved for the treatment of community- acquired pneumonia (CAP) and complicated skin infections. This newly developed cephalosporin possesses a broad spectrum of activity against gram-positive and gram-negative bacteria. Most importantly, ceftaroline demonstrates potent in vitro antimicrobial activity against multi-drug resistant Streptococcus pn...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: The Journal of emergency medicine

سال: 2021

ISSN: ['2352-5029', '0736-4679']

DOI: https://doi.org/10.1016/j.jemermed.2021.02.001