Oral 5-Day Lefamulin for Outpatient Management of Community-Acquired Bacterial Pneumonia: Post-hoc Analysis of the Lefamulin Evaluation Against Pneumonia (LEAP) 2 Trial
نویسندگان
چکیده
BackgroundSafe and effective oral antibiotics are needed for outpatient management of moderate to severe community-acquired bacterial pneumonia (CABP).ObjectiveWe describe a post-hoc analysis adults with CABP managed as outpatients from the Lefamulin Evaluation Against Pneumonia (LEAP) 2 double-blind, noninferiority, phase 3 clinical trial.MethodsLEAP compared efficacy safety lefamulin 600 mg every 12 h (5 days) vs. moxifloxacin 400 24 (7 in (inpatients outpatients) Outcomes Research Team (PORT) risk classes II‒IV.ResultsOverall, 41% (151 368) patients receiving 43% (159 started treatment outpatients—44% 40%, respectively, were PORT class III/IV, 21% both groups had CURB-65 scores 2‒3. Early response (at 96 ± h) investigator assessment success rates at test cure (5‒10 days after last study drug dose) high similar among all (lefamulin, 91% moxifloxacin, 89‒90%), III/IV (89‒91% 88‒91%), score 2‒3 (87‒90% 82‒88%) outpatients. Few 2.6%; 2.5%) discontinued because treatment-emergent adverse events (TEAEs). No group was hospitalized TEAE, 5 (3%), including two deaths, group.ConclusionsThese data suggest that can be given lieu fluoroquinolones or
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ژورنال
عنوان ژورنال: The Journal of emergency medicine
سال: 2021
ISSN: ['2352-5029', '0736-4679']
DOI: https://doi.org/10.1016/j.jemermed.2021.02.001